Reach Us +44 1625708989


Promising Biomarkers to Predict the Efficacy of Inhibitors of the Epidermal Growth Factor Receptor Tyrosine Kinase in Head and Neck Squamous Cell Carcinoma

The Epidermal Growth Factor Receptor (EGFR) is overexpressed in most Head and Neck Squamous Cell Carcinomas (HNSCCs), making EGFR an important therapeutic target. Although specific mutations in EGFR sensitize inhibitors of the EGFR tyrosine kinase, these mutations are rarely observed in HNSCCs. Early clinical trials of monotherapy with EGFR inhibitors in patients with HNSCC have therefore yielded disappointing results. Clinical response rates to EGFR inhibitors may be improved by identifying suitable biomarker(s). One such promising biomarker is PIK3CA, which encodes phosphoinositide 3-kinase catalytic subunit α isoform; mutations in this gene may predict the efficacy of EGFR inhibitors.


Yuh Baba and Yasumasa Kato

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
30+ Million Readerbase
Recommended Conferences
Flyer image
Abstracted/Indexed in
  • Index Copernicus
  • Google Scholar
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Secret Search Engine Labs