Plasma Hyaluronan Decreases During ICU Stay in COVID-19 Survivors but Not in Non-Survivor: A Retrospective Cohort Study

Plasma hyaluronan concentration is associated with disease severity in COVID-19 patients. Hyaluronan is found in secretions and alveolar exudate in COVID-19 patients, and increased perialveolar interstitial hyaluronan has been found in the lungs of COVID-19 patients. This may obstruct alveoli and impair gas exchange and thereby contribute to hypoxemia and respiratory failure. The aim of this study was to describe the dynamics of plasma hyaluronan concentrations and to compare hyaluronan concentrations between non-survivors and survivors in critically ill COVID-19 patients.


Jaap Van Der Heijden, Constantinos Kolliopoulos, Karl Stattin, Miklos Lipcsey, Robert Frithiof, Masood Kamali-Moghaddam, Anders Larsson, Chun-Yu Lin, Jyrki Tenhunen, Michael Hultström and Paraskevi Heldin

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