Leiomyoma with bizarre nuclei (LM-BN) is a rare uterine smooth muscle tumor characterized by a remarkable nuclear atypia reminiscent of its malignant counterpart leiomyosarcoma (LMS). While it presents with an overall benign clinical course, the biological nature and pathogenesis of LM-BN remains largely unknown. The controversy about the rÃ?à ¯Ã?Ã?à ½nÃÂà ?à ÂÃ? between LM-BN and benign and malignant uterine smooth muscle tumors remains unresolved. To date, the diagnosis of LM-BN relies mainly on morphological cà ?Ã?rÃ?cÃ?Ã?rà ÂÃÂÃ?cÃÂÃ? and no Ã?ëÃ?cÃ?Ã?Ã? molecular markers have been established. Here we describe and summarize recent progress in understanding this unique tumor Ã?nÃ?Ã?yÃ? with a focus on new înÃ?à Ânà Âàregarding molecular and genomic Ã?à ¯Ã?Ã?rÃ?Ã?à ½nàand the Ã?à ½Ã?Ã?nÃ?Ã?à ¯ rÃ?à ¯Ã?Ã?à ½nÃÂà ?à ÂÃ? of LM-BN with LMS.
Tingting Gao1,2 , Chunfang Ha2 , Ping Yin3 , Qing Zhang4 , Yongchao Huang5 , Young Dai5 , Serdar E. Bulun3 and Jian-Jun Wei1,3