Any holistic medicine, if it is to be truly “holistic”, cannot possibly take the policy of escapism from Clinical Trials. The intention to design experimental trials on animals before coming over to humankind has been focused on to procreate the most state-of-the-art clinical trials for human holistic medicine. Thus, split-plots (and even: Split-split plots) are brought at work to employ the full efficiency of Bayesian statistics for purposes of holistically infer posterior likelihood in cases of predictions based on “priors”. This spells that on the on the one hand clinical trials are not necessarily to be of randomized nature. On the other hand, the basic ideas of HCT (Holistic Clinical Trials) and ICT (Integrative Clinical Trials) by means of incorporating Algebraic-Topologic notions (rather than simple numerically crunched data analysis) into the main body of any trial of clinical essence, thence, emerges to be the most applicable handy clinical trials of near-future medicine.