Etiopathogenesis of Inflammatory Bowel Diseases

Non-specific Inflammatory Bowel Diseases (IBD) are particularly troublesome diseases affecting the human digestive tract, in particular the intestine. These diseases manifest themselves in chronic intestinal inflammation that is difficult to control, with periods of uncontrolled exacerbations and self-reminiscent occurrences. Depending on the symptoms and their location in the human gastrointestinal tract, these diseases may occur in various forms. Among the two most common forms of these diseases, Ulcerative Colitis (UC), and Crohn's Disease (CD) can be distinguished. Although the underlying cause of activation as well as the subsequent development of these diseases is not clearly defined, these disorders are known to have autoimmune background. The pathogenesis of IBD is associated with chronic idiopathic, recurrent, inflammatory-mediated gastrointestinal inflammation. The disease may be caused by changes in genes caused by various factors or family genetic predisposition. Exposure to a range of environmental risk factors may lead to disease activation in susceptible individuals. Many of the various factors mentioned in the article, which people are exposed to in their lives, may influence the development of these diseases.

Author(s):

Jerzy Mrowicki, Malgorzata Mrowicka, Adam Dziki, Lukasz Dziki and Ireneusz Majsterek*

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