In the recent years the uses and applications of pesticides has been tremendously increased and therefore the risk of exposure to human also increased with adverse health effects including neurotoxicological alterations. Pesticide residues and their metabolites have been detected in dietary constituents, food materials, tissues, maternal blood and breast milk, which are further linked to the developer and neurological disorders. Biomarkers are considered as an important determinant for the examination of organ function, investigation of diseased conditions and therefore could be useful for the analysis procedure. In view of the increasing risk of human health through pesticide exposure, the present review has been focused on the use of biomarkers in pesticide induced biochemical and neurochemical alterations which could help in biomonitoring studies of populations exposed to pesticides along with the main routes of uptake and mechanism of action, which can be used to monitor risk assessment in occupational settings.
Rajesh Kumar Kori, Abhishek Kumar Jain and Rajesh Singh Yadav*