Abstract

Aging Biomarkers-Disorders Characterized by Premature Aging

Aging is a normal and multi-factorial phenomenon
characterized by the accumulation of degenerative
processes that are in turn underpinned within molecular
pathways by multiple alterations and damage, ultimately
the alterations and damage compromise cell and tissue
functions. As such, for almost all non-communicable
diseases, including cardiovascular diseases, cancer, diabetes
and neurological diseases, aging is the most profound risk
factor. DNA injury, changes in gene and non-coding RNA
expression, genotoxicity, oxidative stress, and the
occurrence of shorter telomeres are the proposed
mechanisms that lead to the aging process and the
development of these chronic, age-associated diseases.


Author(s):

Deeraja Manvi Gatta and Sai Sravani Botcha



Abstract | PDF

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