Heart failure (HF) is a global public health concern that continues to have a sufficient impact on morbidity, mortality and disability in developing ad developed countries. Contemporary diagnostic and prediction strategy bases on biomarker use, which helps improving individual prognostication and early verification of the disease. However, widely implementing biomarkers such as natriuretic peptides, and several new biomarkers (glectin-3, soluble ST2 and others) were not demonstrated strong ability to improve discriminative capacity in various HF phenotypes. In this context micro vesicle (MVs), which play a core role in the endogenous reparation, coagulation, inflammation, immunity and metabolic memory phenomenon, could be prospective biomarkers in HF with predictive ability. However, there is not yet strong evidence those immune phenotypes of MVs are important for prediction and development of several phenotypes of HF. The aim of the review: to summarize knowledge regarding the role of various MVs in diagnosis and prognosis of HF.