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Abstract

Expression Profiles and Mechanisms of microRNAs in Prostate Cancer

MicroRNAs are small non-coding RNA molecules with a length of 20 to 25 nucleotides. As gene expression regulators, microRNAs can completely or not completely complementarily bind with mRNA to inhibit translation or degradate mRNA. Aberrant expression of microRNAs is closely related to the occurrence, development, metastasis and prognosis of prostate cancer. Some microRNAs may promote cancerization, while others are tumor suppressors. In this review, we summarized the expression profiles of microRNAs in recent years, in particular, the data obtained by large-scale high-throughput technologies. We also summed up microRNAs which had the potential to be biomarkers of prostate cancer, and the mechanisms of microRNAs in the developmental progression of prostate cancer. The review provided medical and scientific researchers with an overview of the status and role of microRNAs in prostate cancer. In short, we summarized the expression profiles of microRNAs discovered in recent years and their roles and mechanisms in the occurrence and development of prostate cancer.


Author(s):

Song C, Chen H and Chunyu S



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  • China National Knowledge Infrastructure (CNKI)
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